[Biochemical markers troponin I, leptin and CK-MB in coronary artery diseases]

In recent years, troponin I has been a prognostic factor of myocardial cell injury. Also, regarding the importance of leptin measurement in coronary artery disease investigations are being performed. In addition, CK-MB has been a "gold standard" test for this disease. The aim of this study was to assess the biochemical markers Troponin I, Leptin and CK-MB in coronary artery diseases. This was a study on 100 patients who suffered from coronary artery disease. Following blood collection, the serum sample was tested to determine the concentration of troponin I, Leptin, and CK-MB. Troponin I level was measured by two-site immunoluminometric assay. Leptin and CK-MB levels were detected by ELISA. Statistical t-test was employed to analyze the data. The data obtained in the present study was indicative of a significant correlation between troponin I and Leptin among the patients [p=0.01]. Also, a significant relationship was observed between troponin I and CK-MB in our study population [p=0.01]. In addition, there was a significant relationship between both leptin and troponin 1 and the gender [p<0.001; p<0.016]. Leptin was also found to have a significant association with age [p=0.018]. Finally, a significant correlation between the history of myocardial infarction and gender was demonstrated [p<0.002]. Our results showed that the measurement of troponin I in combination with CK-MB, as gold standard, could be considered as an appropriate diagnostic method for progress of myocardial infarction. Leptin and troponin I are also suitable biomarkers in diagnosis of coronary artery diseases. Due to lack of troponin I in other body tissues except for cardiac tissue, troponin I is proposed as an ideal marker for definite diagnosis of acute myocardial infarction

[Efficacy of 0.05% topical solution of tretinoin on healing of chronic ulcers and comparison of it with 1% topical cream of phenytoin]

Chronic ulcer with any kind of etiology is one of the therapeutic problems for patients and medical services. With respect to appropriate effects of retinoids on different stages of wound healing, we decided to evaluate efficacy of 0.05% topical solution of tretinoin on topical treatment of ulcers in comparison with 1% topical cream of phenytoin,that its effects on wound healing has been approved in several studies. In an interventional, clinical trial topical effect of these two drugs on healing of chronic ulcers of 30 patients with 37 ulcers was compared, with random allocation patients divided to two groups and finally 15 patients with 18 ulcers treated with l%topical cream of phenytoin and 15 patients with 19 ulcers treated with 0.05% topical solution of tretinoin. Then followed up for 6 weeks and evaluated for criteria of clinical recovery [size, depth, secretion and pain] in weekly visits. Analytic tests were done by using the chi-square test and P<0.05 was accepted as significant. 'At the end of, the treatment in phenytoin group 42.6 +/- 44.9% and in tretinoin group 44.7 +/- 43.4% of ulcers width were reduced. Also at this time ulcers' depth were diminished whereas in phenytoin group 55.6% and in tretinoin group 26.3% of those were in superficial dermis. Before treatment in phenytoin group 55.6% of ulcers were without pain though after it 100% of them had no pain. In tretinoin group ulcers without pain increased from 78.9% before to 84.2% after treatment. Percentage of ulcers with no secretion increased from 33.3% to 55.6% in phenytoin group and from 26.3% to 68.4% in tretinoin group With respect to results, tretinoin solution as phenytoin cream can be used as an appropriate topical treatment for chronic ulcer